First you must includes WordPress basic functions:
// Include WordPress
define('WP_USE_THEMES', false);
global $wpdb;And then run your loop on any PHP file even OUTSIDE your WordPress website.
require('/server/path/to/your/wordpress/site/htdocs/blog/wp-blog-header.php');
query_posts('showposts=1');
<?php while (have_posts()): the_post(); ?>
<h2><?php the_title(); ?></h2>
<?php the_excerpt(); ?>
<p><a href="<?php the_permalink(); ?>" class="red">Read more...</a></p>
<?php endwhile; ?>